
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular options as drug targets and antibody-drug conjugates for remedy
Superior colorectal adenocarcinoma (CRAC), featured by distinctive histopathological look, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a bunch of heterogeneous cancers with distinctive genetic signatures and malignant phenotypes. Therapy of CRAC is a frightening activity for oncologists.
At the moment, numerous methods together with molecular focusing on utilizing therapeutic monoclonal antibodies, small molecule kinase inhibitors and immunoregulatory checkpoint remedy have been utilized to fight this lethal illness. Nevertheless, these therapeutic modalities and approaches obtain solely restricted success. Thus, there’s a pharmaceutical want to find new targets and develop novel therapeutics for CRAC remedy. MET and RON receptor tyrosine kinases have been implicated in CRAC pathogenesis.
Scientific research have revealed that aberrant MET and/or RON expression and signaling are essential in regulating CRAC development and malignant phenotypes. Elevated MET and/or RON expression additionally has prognostic worth for CRAC development and affected person survival.
These options present the rationale to focus on MET and RON for scientific CRAC intervention. At current, using small molecule kinase inhibitors focusing on MET for CRAC therapy has achieved vital progress with a number of approvals for scientific utility.
Nonetheless, antibody-based biotherapeutics, though beneath scientific trials for greater than Eight years, have made little or no progress. On this assessment, we focus on the significance of MET and/or RON in CRAC tumorigenesis and growth of anti-MET, anti-RON, and MET and RON-dual focusing on antibody-drug conjugates for scientific utility. The findings from each preclinical research and scientific trials spotlight the potential of this novel kind of biotherapeutics for CRAC remedy sooner or later.

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4-MAA447Po21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Biotin. |
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4-MAA447Po21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Cy3. |
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4-MAA447Po21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with FITC. |
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4-MAA447Po21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with HRP. |
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4-MAA447Po21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with PE. |
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4-MAA447Ra21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC. |
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4-MAA447Ra21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin. |
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4-MAA447Ra21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3. |
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4-MAA447Ra21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC. |
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4-MAA447Ra21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP. |
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4-MAA447Ra21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE. |
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4-MAA447Ra28-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC. |
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4-MAA447Ra28-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin. |
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4-MAA447Ra28-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3. |
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4-MAA447Ra28-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC. |
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4-MAA447Ra28-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP. |
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4-MAA447Ra28-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE. |
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20-abx130478 | Abbexa |
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20-abx130479 | Abbexa |
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20-abx132114 | Abbexa |
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20-abx176030 | Abbexa |
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20-abx176031 | Abbexa |
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DLR-C-Peptide-c-48T | DL Develop | 48T | EUR 527 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-C-Peptide-c-96T | DL Develop | 96T | EUR 688 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RD-C-Peptide-c-48Tests | Reddot Biotech | 48 Tests | EUR 533 |
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RD-C-Peptide-c-96Tests | Reddot Biotech | 96 Tests | EUR 740 |
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RDR-C-Peptide-c-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
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RDR-C-Peptide-c-96Tests | Reddot Biotech | 96 Tests | EUR 774 |
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DLR-C-Peptide-Mu-48T | DL Develop | 48T | EUR 450 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-C-Peptide-Mu-96T | DL Develop | 96T | EUR 582 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RD-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 446 |
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RD-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 615 |
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RDR-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 465 |
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RDR-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 643 |
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4-MAA447Po21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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4-MAA447Ra21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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4-MAA447Ra28-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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20-abx108948 | Abbexa |
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20-abx106115 | Abbexa |
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20-abx107529 | Abbexa |
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20-abx272515 | Abbexa |
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MA1011 | BosterBio | 100ug/vial | EUR 334 |
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CEA447Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4391.16 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 449.27 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 598.96 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2395.32 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CEA447Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse C-Peptide (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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20-abx490109 | Abbexa |
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RK02705 | Abclonal | 96 Tests | EUR 521 |
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DLR-C-Peptide-Hu-48T | DL Develop | 48T | EUR 398 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-C-Peptide-Hu-96T | DL Develop | 96T | EUR 511 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-C-Peptide-Ra-48T | DL Develop | 48T | EUR 467 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-C-Peptide-Ra-96T | DL Develop | 96T | EUR 605 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RD-C-Peptide-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 387 |
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RD-C-Peptide-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 532 |
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RD-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 465 |
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RD-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 643 |
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RDR-C-Peptide-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 404 |
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RDR-C-Peptide-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 556 |
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RDR-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 486 |
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RDR-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 672 |
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20-abx651801 | Abbexa |
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DLR-CP-Mu-48T | DL Develop | 48T | EUR 489 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ceruloplasmin (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-CP-Mu-96T | DL Develop | 96T | EUR 635 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ceruloplasmin (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RDR-CP-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 511 |
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RDR-CP-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 709 |
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RD-CP-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 489 |
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RD-CP-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 677 |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
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4-PAA447Ga01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP) |
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4-PAA447Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP) |
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4-PAA447Po01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP) |
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4-CPA447Ga31 | Cloud-Clone |
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Description: Recombinant Chicken C-Peptide expressed in: Protein conjugation |
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4-CPA447Gu31 | Cloud-Clone |
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Description: Recombinant Guinea pig C-Peptide expressed in: Protein conjugation |
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4-CPA447Hu21 | Cloud-Clone |
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Description: Recombinant Human C-Peptide expressed in: Protein conjugation |
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4-CPA447Po11 | Cloud-Clone |
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Description: Recombinant Pig C-Peptide expressed in: Protein conjugation |
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4-CPA447Po21 | Cloud-Clone |
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Description: Recombinant Pig C-Peptide expressed in: Protein conjugation |
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4-CPA447Ra11 | Cloud-Clone |
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Description: Recombinant Rat C-Peptide expressed in: Protein conjugation |
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4-CPA447Ra21 | Cloud-Clone |
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Description: Recombinant Rat C-Peptide expressed in: Protein conjugation |
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4-CPA447Ra31 | Cloud-Clone |
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Description: Recombinant Rat C-Peptide expressed in: Protein conjugation |
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STJ29972 | St John's Laboratory | 100 µl | EUR 277 |
Description: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
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STJ115616 | St John's Laboratory | 100 µl | EUR 277 |
Description: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
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DF9369-BP | Affbiotech | 1mg | EUR 195 |
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4-PAA447Ga01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with APC. |
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4-PAA447Ga01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with Biotin. |
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4-PAA447Ga01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with Cy3. |
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4-PAA447Ga01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with FITC. |
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4-PAA447Ga01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with HRP. |
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4-PAA447Ga01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with PE. |
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4-PAA447Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC. |
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4-PAA447Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with Biotin. |
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4-PAA447Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with Cy3. |
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4-PAA447Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with FITC. |
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4-PAA447Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with HRP. |
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4-PAA447Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with PE. |
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4-PAA447Po01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with APC. |
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4-PAA447Po01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with Biotin. |
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4-PAA447Po01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with Cy3. |
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4-PAA447Po01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with FITC. |
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4-PAA447Po01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with HRP. |
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4-PAA447Po01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with PE. |
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CCA447Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5647.8 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 552.76 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 746.8 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3060.6 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CCA447Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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CCA447Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6119.04 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Ra-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 591.57 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Ra-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 802.24 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CCA447Ra-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3310.08 |
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Description: This is Competitive Chemiluminescent immunoassay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CCA447Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
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CEA447Ca-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4862.4 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Dog C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ca-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 488.08 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Dog C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ca-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 654.4 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Dog C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ca-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2644.8 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Dog C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CEA447Ca | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Dog C-Peptide (CP) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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CEA447Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 3291.6 |
|
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 358.72 |
|
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 469.6 |
|
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 1813.2 |
|
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CEA447Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human C-Peptide (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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CEA447Po-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5098.02 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Pig C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Po-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 507.48 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Pig C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Po-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 682.12 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Pig C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Po-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2769.54 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Pig C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CEA447Po | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Pig C-Peptide (CP) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
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CEA447Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4129.36 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ra-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 427.71 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ra-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 568.16 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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CEA447Ra-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2256.72 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat C-Peptide (CP) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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4-CEA447Ra | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Rat C-Peptide (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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20-abx190104 | Abbexa |
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20-abx190623 | Abbexa |
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20-abx490108 | Abbexa |
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20-abx490110 | Abbexa |
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RK01170 | Abclonal | 96 Tests | EUR 521 |
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RK03588 | Abclonal | 96 Tests | EUR 521 |
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4-MAA909Hu21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ceruloplasmin (CP) |
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4-MAA909Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ceruloplasmin (CP) |
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4-MAA909Ra21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Ceruloplasmin (CP) |
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4-PAA447Ga01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Chicken C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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4-PAA447Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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4-PAA447Po01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig C-Peptide (CP). This antibody is labeled with APC-Cy7. |
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PB9852 | BosterBio | 100ug/vial | EUR 334 |
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PB9853 | BosterBio | 100ug/vial | EUR 334 |
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DLR-CP-Hu-48T | DL Develop | 48T | EUR 441 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Ceruloplasmin (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-CP-Hu-96T | DL Develop | 96T | EUR 570 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Ceruloplasmin (CP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-CP-Ra-48T | DL Develop | 48T | EUR 508 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Ceruloplasmin (CP) in samples from serum, plasma or other biological fluids. |
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DLR-CP-Ra-96T | DL Develop | 96T | EUR 661 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Ceruloplasmin (CP) in samples from serum, plasma or other biological fluids. |
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RDR-CP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 455 |
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RDR-CP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 629 |
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RDR-CP-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 534 |
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RDR-CP-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 742 |
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RD-CP-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 436 |
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RD-CP-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 601 |
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RD-CP-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 511 |
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RD-CP-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 709 |
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ELK7346 | ELK Biotech | 1 plate of 96 wells | EUR 526 |
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Description: A competitive Inhibition ELISA kit for detection of C-Peptide from Pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELK7509 | ELK Biotech | 1 plate of 96 wells | EUR 526 |
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Description: A competitive Inhibition ELISA kit for detection of C-Peptide from Dog in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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KTE90143-48T | Abbkine | 48T | EUR 354 |
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Description: Quantitative sandwich ELISA for measuring Rabbit C-Peptide (CP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Antibody Response to Canine Parvovirus Vaccination in Canines with Hyperadrenocorticism Handled with Trilostane
- It’s unknown how canines with hyperadrenocorticism (HAC) reply to vaccination. This research measured antibodies in opposition to canine parvovirus (CPV) in canines with HAC handled with trilostane earlier than and after CPV vaccination, and in contrast the immune response to that from wholesome canines. Eleven canines with HAC, and wholesome age-matched management canines (n = 31) obtained a modified-live CPV vaccine. Antibodies have been decided on days 0, 7, and 28 by hemagglutination inhibition. Univariate evaluation was used to match the immune response of canines with HAC and wholesome canines.
- Pre-vaccination antibodies (≥10) have been detected in 100% of canines with HAC (11/11; 95% CI: 70.0-100) and in 93.5% of wholesome canines (29/31; 95% CI: 78.3-99.2). No ≥4-fold enhance in antibody titer was noticed in canines with HAC whereas in 22.6% of wholesome canines, a ≥4-fold titer enhance was noticed (7/31; 95% CI: 11.1-40.1).
- Gentle vaccine-associated antagonistic occasions (VAAEs) have been detected in 54.5% of canines with HAC (6/11; 95% CI: 28.0-78.8) and in 29.0% of wholesome canines (9/31; 95% CI: 15.9-46.8). There was neither a vital distinction in presence of pre-vaccination antibodies (p = 1.000), or response to vaccination (p = 0.161), nor within the prevalence of VAAEs (p = 0.158). Immune perform of canines with HAC handled with trilostane appears similar to that of wholesome canines.
Design and Validation of Linkers for Website-Particular Preparation of Antibody-Drug Conjugates Carrying A number of Drug Copies Per Cysteine Conjugation Website
First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are restricted to 1 drug per cysteine. Nevertheless, sure purposes require a excessive drug to antibody ratio (DAR), corresponding to when low-potency payloads are used. Increased drug load may be achieved utilizing classical cysteine conjugation strategies, however these lead to heterogeneity, suboptimal efficacy and pharmacokinetics.
Right here, we describe the design, synthesis and validation of heterobifunctional linkers that can be utilized for the preparation of ADCs with a DAR of two, three and 4 in a site-specific method per single cysteine conjugation website, leading to site-specific ADCs with a DAR of 4, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and a number of cyclic diene moieties which might effectively react with maleimide-carrying payloads via the Diels-Alder response.
As a proof of idea, we synthesized site-specific DAR 4, six and eight ADCs carrying tubulysin (AZ13601508) utilizing engineered antibodies with a cysteine inserted after place 239 within the antibody CH2 area.
We evaluated and in contrast the in vitro cytotoxicity of ADCs obtained by way of the site-specific platform described herein, with ADCs ready utilizing classical cysteine conjugation. Our knowledge validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with excessive drug load for therapeutic purposes.
![]() Mouse Calcitonin (CT) ELISA Kit |
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RD-CT-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 677 |
![]() Canine Calcitonin (CT) ELISA Kit |
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DLR-CT-c-48T | DL Develop | 48T | EUR 527 |
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Description: A sandwich quantitative ELISA assay kit for detection of Canine Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Canine Calcitonin (CT) ELISA Kit |
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DLR-CT-c-96T | DL Develop | 96T | EUR 688 |
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Description: A sandwich quantitative ELISA assay kit for detection of Canine Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Calcitonin (CT) ELISA Kit |
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DLR-CT-Hu-48T | DL Develop | 48T | EUR 441 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Calcitonin (CT) ELISA Kit |
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DLR-CT-Hu-96T | DL Develop | 96T | EUR 570 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Rat Calcitonin (CT) ELISA Kit |
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DLR-CT-Ra-48T | DL Develop | 48T | EUR 508 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Rat Calcitonin (CT) ELISA Kit |
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DLR-CT-Ra-96T | DL Develop | 96T | EUR 661 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Calcitonin (CT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Canine Calcitonin (CT) ELISA Kit |
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RDR-CT-c-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
![]() Canine Calcitonin (CT) ELISA Kit |
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RDR-CT-c-96Tests | Reddot Biotech | 96 Tests | EUR 774 |
![]() Human Calcitonin (CT) ELISA Kit |
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RDR-CT-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 455 |
![]() Human Calcitonin (CT) ELISA Kit |
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RDR-CT-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 629 |
![]() Rat Calcitonin (CT) ELISA Kit |
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RDR-CT-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 534 |
![]() Rat Calcitonin (CT) ELISA Kit |
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RDR-CT-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 742 |
![]() Canine Calcitonin (CT) ELISA Kit |
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RD-CT-c-48Tests | Reddot Biotech | 48 Tests | EUR 533 |
![]() Canine Calcitonin (CT) ELISA Kit |
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RD-CT-c-96Tests | Reddot Biotech | 96 Tests | EUR 740 |
![]() Human Calcitonin (CT) ELISA Kit |
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RD-CT-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 436 |
![]() Human Calcitonin (CT) ELISA Kit |
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RD-CT-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 601 |
![]() Rat Calcitonin (CT) ELISA Kit |
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RD-CT-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 511 |
![]() Rat Calcitonin (CT) ELISA Kit |
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RD-CT-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 709 |
![]() monoclonal anti-Human Calcitonin (CT) IgG |
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CT12-M | Alpha Diagnostics | 100 ug | EUR 482 |
![]() Calcitonin (CT) Monoclonal Antibody (Human) |
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4-MAA472Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT) |
![]() Calcitonin (CT) Monoclonal Antibody (Rat) |
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4-MAA472Ra21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT) |
![]() monoclonal anti-Human Calcitonin (CT) IgG #2 |
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CT13-M | Alpha Diagnostics | 100 ug | EUR 482 |
![]() Calcitonin (CT) Monoclonal Antibody (Human), APC |
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4-MAA472Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with APC. |
![]() Calcitonin (CT) Monoclonal Antibody (Human), Biotinylated |
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4-MAA472Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with Biotin. |
![]() Calcitonin (CT) Monoclonal Antibody (Human), Cy3 |
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4-MAA472Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with Cy3. |
![]() Calcitonin (CT) Monoclonal Antibody (Human), FITC |
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4-MAA472Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with FITC. |
![]() Calcitonin (CT) Monoclonal Antibody (Human), HRP |
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4-MAA472Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with HRP. |
![]() Calcitonin (CT) Monoclonal Antibody (Human), PE |
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4-MAA472Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with PE. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), APC |
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4-MAA472Ra21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), Biotinylated |
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4-MAA472Ra21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Biotin. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), Cy3 |
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4-MAA472Ra21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Cy3. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), FITC |
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4-MAA472Ra21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with FITC. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), HRP |
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4-MAA472Ra21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with HRP. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), PE |
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4-MAA472Ra21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with PE. |
![]() Calcitonin (CT) Antibody |
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20-abx175651 | Abbexa |
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![]() Calcitonin (CT) Antibody |
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20-abx100227 | Abbexa |
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![]() Calcitonin (CT) Antibody |
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20-abx100228 | Abbexa |
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![]() Calcitonin (CT) Antibody |
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20-abx100230 | Abbexa |
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![]() Calcitonin (CT) Antibody |
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20-abx104916 | Abbexa |
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![]() Calcitonin (CT) Antibody |
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20-abx171510 | Abbexa |
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![]() Calcitonin (CT) Polyclonal Antibody (Mouse) |
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4-PAA472Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Calcitonin (CT) |
![]() Mouse Calcitonin (CT) Protein |
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20-abx065656 | Abbexa |
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![]() Calcitonin (CT) Monoclonal Antibody (Human), APC-Cy7 |
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4-MAA472Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with APC-Cy7. |
![]() Calcitonin (CT) Monoclonal Antibody (Rat), APC-Cy7 |
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4-MAA472Ra21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC-Cy7. |
![]() Calcitonin (CT) Antibody (Biotin) |
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20-abx271724 | Abbexa |
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![]() Calcitonin (CT) Antibody (Biotin) |
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20-abx271988 | Abbexa |
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![]() Recombinant Calcitonin (CT) |
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4-RPA472Ca01 | Cloud-Clone |
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Description: Recombinant Dog Calcitonin expressed in: E.coli |
![]() Recombinant Calcitonin (CT) |
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4-RPA472Hu01 | Cloud-Clone |
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Description: Recombinant Human Calcitonin expressed in: E.coli |
![]() Recombinant Calcitonin (CT) |
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4-RPA472Mu01 | Cloud-Clone |
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