
Distinctive repertoire of anti-carbohydrate antibodies in particular person human serum
- Humoral immunity to pathogens and different environmental challenges is paramount to preserve regular well being, and people missing or unable to make antibodies are in danger. Current research point out that many human protecting antibodies are in opposition to carbohydrate antigens; nonetheless, little is thought about repertoires and particular person variation of anti-carbohydrate antibodies in wholesome people.
- Right here we analyzed anti-carbohydrate antibody repertoires (ACARs) of 105 wholesome particular person grownup donors, aged 20-60+ from totally different ethnic backgrounds to discover variations in antibodies, as outlined by binding to glycan microarrays and by affinity purification. Utilizing microarrays that contained > 1,000 glycans, together with antigens from animal cells and microbes, we profiled the IgG and IgM ACARs from all donors.
- Every donor expressed many ACAs, however had a comparatively distinctive ACAR, which included unanticipated antibodies to carbohydrate antigens not properly studied, corresponding to chitin oligosaccharides, Forssman-related antigens, globo-type antigens, and bacterial glycans. We additionally noticed some anticipated antibodies to ABO(H) blood group and α-Gal-type antigens,
- though these additionally diversified amongst people. Evaluation suggests variations in ACARs are related to ethnicity and age. Thus, every particular person ACAR is comparatively distinctive, suggesting that individualized data may very well be helpful in precision drugs for predicting and monitoring immune well being and resistance to illness.

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DLR-IL8-Ch-96T | DL Develop | 96T | EUR 531 |
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Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-IL8-Fi-96T | DL Develop | 96T | EUR 654 |
Description: A sandwich quantitative ELISA assay kit for detection of Fish Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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DLR-IL8-Hu-48T | DL Develop | 48T | EUR 333 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-IL8-Hu-96T | DL Develop | 96T | EUR 420 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-IL8-Rb-96T | DL Develop | 96T | EUR 587 |
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-IL8-Si-48T | DL Develop | 48T | EUR 474 |
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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DLR-IL8-Si-96T | DL Develop | 96T | EUR 614 |
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8) |
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4-MAA080Ga22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8) |
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8) |
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8) |
![]() Guinea pig Interleukin 8 (IL8) ELISA Kit |
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DLR-IL8-Gu-48T | DL Develop | 48T | EUR 388 |
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Guinea pig Interleukin 8 (IL8) ELISA Kit |
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DLR-IL8-Gu-96T | DL Develop | 96T | EUR 496 |
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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RDR-IL8-Gu-48Tests | Reddot Biotech | 48 Tests | EUR 391 |
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RDR-IL8-Gu-96Tests | Reddot Biotech | 96 Tests | EUR 538 |
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RD-IL8-Gu-48Tests | Reddot Biotech | 48 Tests | EUR 375 |
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RD-IL8-Gu-96Tests | Reddot Biotech | 96 Tests | EUR 515 |
![]() Interleukin 8 (IL8) Antibody |
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20-abx131832 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx131833 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx131836 | Abbexa |
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20-abx131838 | Abbexa |
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20-abx131839 | Abbexa |
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20-abx100971 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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abx036426-100ug | Abbexa | 100 ug | EUR 391 |
![]() Interleukin 8 (IL8) Antibody |
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20-abx009111 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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abx018002-100ug | Abbexa | 100 ug | EUR 342 |
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abx020956-05mg | Abbexa | 0.5 mg | EUR 1080 |
![]() Interleukin 8 (IL8) Antibody |
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20-abx270103 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx270152 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx270200 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx270201 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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abx216289-100ug | Abbexa | 100 ug | EUR 439 |
![]() Interleukin 8 (IL8) Antibody |
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20-abx177199 | Abbexa |
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![]() Interleukin 8 (IL8) Antibody |
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20-abx177201 | Abbexa |
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20-abx173191 | Abbexa |
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The genetic foundation of pure antibodytiters of younger wholesome pigs and relationships with illness resilience
Background: Illness resilience is the power to keep up efficiency beneath pathogen publicity however is tough to pick for as a result of breeding populations are raised beneath excessive well being. Choice for resilience requires a trait that’s heritable, simple to measure on wholesome animals, and genetically correlated with resilience. Pure antibodies (NAb) are essential elements of the innate immune system and are discovered to be heritable and related to illness susceptibility in dairy cattle and poultry. Our goal was to analyze NAb and complete IgG in blood of wholesome, younger pigs as potential indicator traits for illness resilience.
Outcomes: Knowledge have been from Yorkshire x Landrace pigs, with IgG and IgM NAb (4 antigens) and complete IgG measured by ELISAin blood plasma collected ~ 1 week after weaning, previous to their publicity to a pure polymicrobial problem. Heritability estimates have been decrease for IgG NAb (0.12 to 0.24, + 0.05) and for complete IgG (0.19 + 0.05) than for IgM NAb (0.33 to 0.53, + 0.07) however maternal results have been bigger for IgG NAb (0.41 to 0.52, + 0.03) and for complete IgG (0.19 + 0.05) than for IgM NAb (0.00 to 0.10, + 0.04).
Phenotypically, IgM NAbtiters have been reasonably correlated with one another (common 0.60), as have been IgG NAbtiters (common 0.42), however correlations between IgM and IgG NAbtiters have been weak (common 0.09). Phenotypic correlations of complete IgG have been reasonable with NAb IgG (common 0.46) however weak with NAb IgM (common 0.01).
Estimates of genetic correlations amongst NAb confirmed comparable patterns however with small SE, with estimates averaging 0.76 amongst IgG NAb, 0.63 amongst IgM NAb, 0.17 between IgG and IgM NAb, 0.64 between complete IgG and IgG NAb, and 0.13 between complete IgG and IgM NAb. Phenotypically, pigs that survived had barely greater ranges of NAb and complete IgG than pigs that died.
Genetically, greater ranges of NAb tended to be related to better illness resilience primarily based on decrease mortalityand fewer parenteral antibiotic remedies. Genome-wide affiliation analyses for NAbtiters recognized a number of genomic areas, with a number of candidate genes for immune response.
Conclusions: Ranges of NAb in blood of wholesome younger piglets are heritable and potential genetic indicators of resilience to polymicrobial illness.
COVID-19 confirmed sufferers with adverse antibodies outcomes
Background: A brand new coronavirus illness 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of sufferers might have issue in producing IgM or IgG antibodies in opposition to SARS-CoV-2, and little consideration has been paid to them.
Case shows: We current two instances of confirmed COVID-19 sufferers and characterize their preliminary signs, chest CT outcomes, medicine, and laboratory check leads to element (together with RT-PCR, IgM/ IgG, cytokine and blood cell counts).
Conclusion: Each of sufferers with confirmed COVID-19 pneumonia failed to provide both IgM or IgG even 40 to 50 days after their signs onset. This work supplies proof demonstrating that at the very least a small proportion of sufferers might have issue in quickly gaining immunity in opposition to SARS-CoV-2.
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RDR-REN-c-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
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![]() Canine Renin (REN) ELISA Kit |
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DLR-REN-c-48T | DL Develop | 48T | EUR 527 |
Description: A sandwich quantitative ELISA assay kit for detection of Canine Renin (REN) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Canine Renin (REN) ELISA Kit |
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DLR-REN-c-96T | DL Develop | 96T | EUR 688 |
Description: A sandwich quantitative ELISA assay kit for detection of Canine Renin (REN) in samples from serum, plasma, tissue homogenates or other biological fluids. |
![]() Human Renin (REN) ELISA Kit |
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DLR-REN-Hu-48T | DL Develop | 48T | EUR 398 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Renin (REN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Renin (REN) ELISA Kit |
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DLR-REN-Hu-96T | DL Develop | 96T | EUR 511 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Renin (REN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Rat Renin (REN) ELISA Kit |
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DLR-REN-Ra-48T | DL Develop | 48T | EUR 508 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Renin (REN) in samples from serum, plasma or other biological fluids. |
![]() Rat Renin (REN) ELISA Kit |
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DLR-REN-Ra-96T | DL Develop | 96T | EUR 661 |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Renin (REN) in samples from serum, plasma or other biological fluids. |
![]() Rabbit Renin (REN) ELISA Kit |
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DLR-REN-Rb-48T | DL Develop | 48T | EUR 508 |
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Renin (REN) in samples from serum, plasma or other biological fluids. |
![]() Rabbit Renin (REN) ELISA Kit |
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DLR-REN-Rb-96T | DL Develop | 96T | EUR 661 |
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Renin (REN) in samples from serum, plasma or other biological fluids. |
![]() Renin (REN) Monoclonal Antibody (Rat) |
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4-MAA889Ra21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN) |
![]() Renin (REN) Antibody |
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20-abx131720 | Abbexa |
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![]() Renin (REN) Antibody |
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20-abx133528 | Abbexa |
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![]() Renin (REN) Antibody |
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20-abx100025 | Abbexa |
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![]() Renin (REN) Antibody |
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![]() Renin (REN) Antibody |
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20-abx100027 | Abbexa |
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20-abx001335 | Abbexa |
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![]() Renin (REN) Antibody |
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abx022848-1mg | Abbexa | 1 mg | EUR 968 |
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abx024055-1mg | Abbexa | 1 mg | EUR 2040 |
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abx024056-1mg | Abbexa | 1 mg | EUR 1261 |
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![]() Renin (REN) Antibody |
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abx145563-100ug | Abbexa | 100 ug | EUR 391 |
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abx237240-100ug | Abbexa | 100 ug | EUR 509 |
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20-abx178248 | Abbexa |
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20-abx174374 | Abbexa |
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![]() Renin (REN) Antibody |
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20-abx174375 | Abbexa |
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![]() Renin (REN) Antibody |
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20-abx174376 | Abbexa |
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![]() Renin (REN) Antibody |
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20-abx324551 | Abbexa |
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![]() Renin (REN) Monoclonal Antibody (Rat), APC |
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4-MAA889Ra21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with APC. |
![]() Renin (REN) Monoclonal Antibody (Rat), Biotinylated |
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4-MAA889Ra21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with Biotin. |
![]() Renin (REN) Monoclonal Antibody (Rat), Cy3 |
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4-MAA889Ra21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with Cy3. |
![]() Renin (REN) Monoclonal Antibody (Rat), FITC |
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4-MAA889Ra21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with FITC. |
![]() Renin (REN) Monoclonal Antibody (Rat), HRP |
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4-MAA889Ra21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with HRP. |
![]() Renin (REN) Monoclonal Antibody (Rat), PE |
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4-MAA889Ra21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with PE. |
![]() Renin (REN) Polyclonal Antibody (Mouse) |
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4-PAA889Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN) |
![]() Renin (REN) Polyclonal Antibody (Mouse) |
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4-PAA889Mu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN) |
![]() Mouse Renin (REN) Protein |
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20-abx068863 | Abbexa |
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![]() Mouse Renin (REN) Protein |
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20-abx068865 | Abbexa |
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![]() Renin (REN) Monoclonal Antibody (Rat), APC-Cy7 |
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4-MAA889Ra21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Rat Renin (REN). This antibody is labeled with APC-Cy7. |
![]() Renin (REN) Antibody (Biotin) |
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20-abx272758 | Abbexa |
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![]() Renin (REN) Antibody (Biotin) |
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20-abx273223 | Abbexa |
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![]() Renin (REN) Antibody (HRP) |
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20-abx314437 | Abbexa |
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![]() Renin (REN) Antibody (FITC) |
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20-abx314438 | Abbexa |
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![]() Renin (REN) Antibody (Biotin) |
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20-abx314439 | Abbexa |
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![]() Renin (REN) Antibody (APC) |
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20-abx178247 | Abbexa |
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![]() Renin (REN) Protein |
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20-abx261100 | Abbexa |
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![]() Recombinant Renin (REN) |
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4-RPA889Hu01 | Cloud-Clone |
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Description: Recombinant Human Renin expressed in: E.coli |
![]() Recombinant Renin (REN) |
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4-RPA889Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Renin expressed in: E.coli |
![]() Recombinant Renin (REN) |
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4-RPA889Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Renin expressed in: E.coli |
![]() Recombinant Renin (REN) |
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4-RPA889Ra01 | Cloud-Clone |
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Description: Recombinant Rat Renin expressed in: E.coli |
![]() Recombinant Renin (REN) |
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4-RPA889Ra02 | Cloud-Clone |
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Description: Recombinant Rat Renin expressed in: E.coli |
![]() Renin (REN) Polyclonal Antibody (Human, Mouse) |
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4-PAA889Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Mouse Renin (REN) |
![]() Renin (REN) Polyclonal Antibody (Mouse), APC |
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4-PAA889Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with APC. |
![]() Renin (REN) Polyclonal Antibody (Mouse), Biotinylated |
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4-PAA889Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with Biotin. |
![]() Renin (REN) Polyclonal Antibody (Mouse), Cy3 |
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4-PAA889Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with Cy3. |
![]() Renin (REN) Polyclonal Antibody (Mouse), FITC |
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4-PAA889Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with FITC. |
![]() Renin (REN) Polyclonal Antibody (Mouse), HRP |
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4-PAA889Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with HRP. |
![]() Renin (REN) Polyclonal Antibody (Mouse), PE |
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4-PAA889Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with PE. |
![]() Renin (REN) Polyclonal Antibody (Mouse), APC |
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4-PAA889Mu02-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with APC. |
![]() Renin (REN) Polyclonal Antibody (Mouse), Biotinylated |
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4-PAA889Mu02-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with Biotin. |
![]() Renin (REN) Polyclonal Antibody (Mouse), Cy3 |
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4-PAA889Mu02-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with Cy3. |
![]() Renin (REN) Polyclonal Antibody (Mouse), FITC |
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4-PAA889Mu02-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with FITC. |
![]() Renin (REN) Polyclonal Antibody (Mouse), HRP |
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4-PAA889Mu02-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with HRP. |
![]() Renin (REN) Polyclonal Antibody (Mouse), PE |
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4-PAA889Mu02-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Renin (REN). This antibody is labeled with PE. |
![]() Mouse Renin (REN) ELISA Kit |
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20-abx154613 | Abbexa |
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![]() Mouse Renin (REN) ELISA Kit |
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abx574051-96tests | Abbexa | 96 tests | EUR 637 |
![]() Mouse Renin (REN) CLIA Kit |
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20-abx492192 | Abbexa |
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![]() Mouse Renin (REN) CLIA Kit |
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abx195121-96tests | Abbexa | 96 tests | EUR 825 |
![]() Mouse Renin ELISA Kit (REN) |
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RK03157 | Abclonal | 96 Tests | EUR 521 |
![]() Mouse REN(Renin) ELISA Kit |
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EM1331 | FN Test | 96T | EUR 476.25 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 56.25pg/ml |
![]() Mouse Renin (REN) ELISA Kit |
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SEA889Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4391.16 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Renin (REN) in serum, plasma and other biological fluids. |
![]() Mouse Renin (REN) ELISA Kit |
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SEA889Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 449.27 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Renin (REN) in serum, plasma and other biological fluids. |
![]() Mouse Renin (REN) ELISA Kit |
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SEA889Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 598.96 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Renin (REN) in serum, plasma and other biological fluids. |
![]() Mouse Renin (REN) ELISA Kit |
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SEA889Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2395.32 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Renin (REN) in serum, plasma and other biological fluids. |