
Affiliation between Neu5Gc carbohydrate and serum antibodies in opposition to it supplies the molecular hyperlink to most cancers: French NutriNet-Santé research
Background: Excessive consumption of pink and processed meat is usually related to elevated most cancers danger, notably colorectal most cancers. Antibodies in opposition to the pink meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate most cancers in “human-like” mice. Human anti-Neu5Gc IgG and pink meat are each independently proposed to extend most cancers danger, but how weight-reduction plan impacts these antibodies is essentially unknown.
Strategies: We used world world knowledge to exhibit that colorectal most cancers incidence and mortality are related to elevated nationwide meat consumption. In a well-defined massive cohort, we used glycomics to measure day by day Neu5Gc consumption from pink meat and dairy, and
investigated serum in addition to affinity-purified anti-Neu5Gc antibodies. Primarily based on 24-h dietary data, day by day Neu5Gc consumption was calculated for 19,621 topics aged ≥ 18 years of the NutriNet-Santé research. Serum and affinity-purified anti-Neu5Gc antibodies have been evaluated by ELISA and glycan microarrays in consultant 120 people, every with at the very least eighteen 24-h dietary data (aged 45-60, Q1-This fall; aged > 60, Q1 and This fall; 10 males/girls per quartile).
Outcomes: We discovered that high-Neu5Gc weight-reduction plan, gender, and age have an effect on the specificity, ranges, and repertoires of anti-Neu5Gc IgG immune responses, however not their affinity. Males consumed extra Neu5Gc than girls, principally from pink meat (p = 0.0015), and exhibited greater general serum anti-Neu5Gc IgG ranges by ELISA (3.94 ng/μl versus 2.22 ng/μl, respectively; p = 0.039). Detailed glycan microarray evaluation in opposition to 56 totally different glycans revealed excessive Neu5Gc-specificity with elevated anti-Neu5Gc IgG and altered repertoires, related to greater consumption of Neu5Gc from pink meat and cow dairy.
Affinity purification of serum anti-Neu5Gc antibodies revealed elevated ranges and biased array repertoire patterns, with out a rise in antibody affinity, in people consuming greater Neu5Gc ranges. Moreover, in a high-meat weight-reduction plan, antibody variety patterns on glycan microarrays shifted in the direction of Neu5Gcα3-linked glycans, rising the α3/α6-glycans ratio rating.
Conclusions: We discovered a transparent hyperlink between the degrees and repertoire of serum anti-Neu5Gc IgG and Neu5Gc consumption from pink meat and dairy. These exact rational methodologies allowed to develop a Gcemic index to simplify the evaluation of Neu5Gc in meals that would doubtlessly be tailored for dietary suggestions to cut back most cancers danger.

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RDR-FBLN3-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
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RDR-FBLN3-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 774 |
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DLR-FBLN3-Hu-48T | DL Develop | 48T | EUR 517 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Fibulin 3 (FBLN3) in samples from serum, plasma, urine or other biological fluids. |
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DLR-FBLN3-Hu-96T | DL Develop | 96T | EUR 673 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Fibulin 3 (FBLN3) in samples from serum, plasma, urine or other biological fluids. |
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RD-FBLN3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 521 |
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RD-FBLN3-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 723 |
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RDR-FBLN3-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 544 |
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4-MAF422Hu21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3) |
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4-MAF422Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3) |
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![]() Fibulin 3 (FBLN3) Monoclonal Antibody (Human), APC |
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4-MAF422Hu21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC. |
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4-MAF422Hu21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Biotin. |
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4-MAF422Hu21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Cy3. |
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4-MAF422Hu21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with FITC. |
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4-MAF422Hu21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with HRP. |
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4-MAF422Hu21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with PE. |
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4-MAF422Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC. |
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4-MAF422Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Biotin. |
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4-MAF422Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Cy3. |
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4-MAF422Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with FITC. |
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4-MAF422Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with HRP. |
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4-MAF422Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with PE. |
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![]() Mouse Fibulin 3 (FBLN3) Protein |
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![]() Recombinant Fibulin 3 (FBLN3) |
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4-RPF422Hu01 | Cloud-Clone |
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Description: Recombinant Human Fibulin 3 expressed in: E.coli |
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4-RPF422Hu02 | Cloud-Clone |
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Description: Recombinant Human Fibulin 3 expressed in: E.coli |
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4-RPF422Ra01 | Cloud-Clone |
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Description: Recombinant Rat Fibulin 3 expressed in: E.coli |
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20-abx272378 | Abbexa |
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4-MAF422Hu21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC-Cy7. |
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4-MAF422Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC-Cy7. |
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![]() Mouse Fibulin 3 ELISA Kit (FBLN3) |
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RK02790 | Abclonal | 96 Tests | EUR 521 |
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SEF422Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4862.4 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
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SEF422Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 488.08 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
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SEF422Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 654.4 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
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SEF422Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2644.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
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4-SEF422Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fibulin 3 (FBLN3) in samples from serum, plasma, urine and other biological fluids with no significant corss-reactivity with analogues from other species. |
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4-PAF422Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3) |
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4-PAF422Hu02 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3) |
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4-PAF422Ra01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3) |
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20-abx650667 | Abbexa |
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20-abx066640 | Abbexa |
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![]() Rat Fibulin 3 (FBLN3) Protein |
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20-abx066641 | Abbexa |
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![]() ELISA kit for Mouse FBLN3 (Fibulin 3) |
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ELK7050 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Fibulin 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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4-PAF422Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), Biotinylated |
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4-PAF422Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Biotin. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), Cy3 |
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4-PAF422Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Cy3. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), FITC |
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4-PAF422Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with FITC. |
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4-PAF422Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with HRP. |
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4-PAF422Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with PE. |
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4-PAF422Hu02-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), Biotinylated |
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4-PAF422Hu02-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Biotin. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), Cy3 |
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4-PAF422Hu02-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with Cy3. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), FITC |
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4-PAF422Hu02-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with FITC. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), HRP |
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4-PAF422Hu02-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with HRP. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), PE |
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4-PAF422Hu02-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with PE. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), APC |
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4-PAF422Ra01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with APC. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), Biotinylated |
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4-PAF422Ra01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with Biotin. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), Cy3 |
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4-PAF422Ra01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with Cy3. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), FITC |
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4-PAF422Ra01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with FITC. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), HRP |
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4-PAF422Ra01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with HRP. |
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4-PAF422Ra01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with PE. |
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EH4179 | FN Test | 96T | EUR 567.6 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.75 ng/ml |
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20-abx151549 | Abbexa |
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![]() Human Fibulin 3 (FBLN3) CLIA Kit |
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![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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abx257697-96tests | Abbexa | 96 tests | EUR 754 |
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SCF422Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5647.8 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Fibulin 3 (FBLN3) in serum, plasma and other biological fluids. |
![]() Human Fibulin 3 (FBLN3)CLIA Kit |
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SCF422Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 552.76 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Fibulin 3 (FBLN3) in serum, plasma and other biological fluids. |
![]() Human Fibulin 3 (FBLN3)CLIA Kit |
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SCF422Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 746.8 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Fibulin 3 (FBLN3) in serum, plasma and other biological fluids. |
![]() Human Fibulin 3 (FBLN3)CLIA Kit |
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SCF422Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3060.6 |
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Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Fibulin 3 (FBLN3) in serum, plasma and other biological fluids. |
![]() Human Fibulin 3 (FBLN3) CLIA Kit |
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4-SCF422Hu | Cloud-Clone |
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Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Fibulin 3 (FBLN3)Serum, plasma and other biological fluids |
![]() Human Fibulin 3 ELISA Kit (FBLN3) |
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RK01362 | Abclonal | 96 Tests | EUR 521 |
![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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SEF422Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4731.5 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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SEF422Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 477.3 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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SEF422Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 639 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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SEF422Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2575.5 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fibulin 3 (FBLN3) in serum, plasma, urine and other biological fluids. |
![]() Human Fibulin 3 (FBLN3) ELISA Kit |
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4-SEF422Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Fibulin 3 (FBLN3) in samples from serum, plasma, urine and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAF422Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC-Cy7. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAF422Hu02-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Fibulin 3 (FBLN3). This antibody is labeled with APC-Cy7. |
![]() Fibulin 3 (FBLN3) Polyclonal Antibody (Rat), APC-Cy7 |
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4-PAF422Ra01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Fibulin 3 (FBLN3). This antibody is labeled with APC-Cy7. |
![]() ELISA kit for Human FBLN3 (Fibulin 3) |
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ELK3553 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Fibulin 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() ELISA kit for Human FBLN3 (Fibulin 3) |
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E-EL-H1673 | Elabscience Biotech | 1 plate of 96 wells | EUR 534 |
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Description: A sandwich ELISA kit for quantitative measurement of Human FBLN3 (Fibulin 3) in samples from Serum, Plasma, Cell supernatant |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
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M00334-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human |
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M00621-3 | BosterBio | 100ug/vial | EUR 334 |
![]() Anti-p16 Monoclonal Antibody |
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A00016-3 | BosterBio | 100ul | EUR 397 |
Description: Mouse Monoclonal Antibody for p16 Antibody (CDKN2A) detection. Tested with WB, IHC in Human, Mouse, Rat. |
![]() Anti-MMP2 Monoclonal Antibody |
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M00286-3 | BosterBio | 100ug | EUR 397 |
Description: Rabbit Monoclonal MMP2 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-Thyroglobulin Monoclonal Antibody |
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M00359-3 | BosterBio | 100ug | EUR 397 |
Description: Rabbit Monoclonal Thyroglobulin Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-PON1 Monoclonal Antibody |
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M00516-3 | BosterBio | 100ug | EUR 397 |
Description: Rabbit Monoclonal PON1 Antibody. Validated in IP, WB and tested in Human, Mouse, Rat. |
![]() Anti-ZAP70 Monoclonal Antibody |
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M00754-3 | BosterBio | 100ug | EUR 397 |
Description: Rabbit Monoclonal ZAP70 Antibody. Validated in IP, IF, WB and tested in Human. |
![]() Anti-HSP90 Monoclonal Antibody |
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M01692-3 | BosterBio | 200ug | EUR 397 |
Description: Mouse Monoclonal HSP90 Antibody. Validated in ELISA, IP, IF, IHC, WB and tested in Human, Mouse, Rat. |
![]() Anti-Trap1 Monoclonal Antibody |
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M02426-3 | BosterBio | 100ug | EUR 397 |
Description: Mouse Monoclonal Trap1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-Fibrillarin Monoclonal Antibody |
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M03178-3 | BosterBio | 100ul | EUR 397 |
Description: Mouse Monoclonal Fibrillarin Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
![]() Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody |
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M02431-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
![]() Anti-Fibulin-3 Antibody |
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A02302 | BosterBio | 100ul | EUR 397 |
Description: Rabbit Polyclonal Antibody for Fibulin-3 Antibody (EFEMP1) detection.tested for WB in Human, Mouse, Rat. |
![]() Anti-Fibulin-3 antibody |
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STJ93073 | St John's Laboratory | 200 µl | EUR 197 |
Description: Rabbit polyclonal to Fibulin-3. |
![]() Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody |
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M00227-3 | BosterBio | 100ul | EUR 397 |
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine. |
![]() Anti-Mouse IgG goat monoclonal antibody, Clone#RMG07 |
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M04575-3 | BosterBio | 100ug | EUR 427 |
Description: Anti-Mouse IgG goat monoclonal antibody, Clone#RMG07 tested in IP, ICC, IHC, FC, ELISA, reactive to Mouse |
![]() Anti-PARP Rabbit Monoclonal Antibody |
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M00122-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-p21 Rabbit Monoclonal Antibody |
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M00145-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal p21 Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
![]() Anti-PAX6 Rabbit Monoclonal Antibody |
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M00273-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal PAX6 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-C-FOS Monoclonal Antibody |
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M00297-3 | BosterBio | 100ul | EUR 397 |
Description: Mouse Monoclonal C-FOS Antibody. Validated in IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
![]() Anti-CD79a Antibody (monoclonal, 4G4) |
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M01047-3 | BosterBio | 100ug/vial | EUR 334 |
![]() Anti-Desmin Antibody (monoclonal, 2B5) |
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M01948-3 | BosterBio | 100ug/vial | EUR 334 |
![]() Anti-Actin Rabbit Monoclonal Antibody |
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M02014-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal Actin Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
![]() Anti-Ubiquitin Rabbit Monoclonal Antibody |
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M02848-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal Ubiquitin Antibody. Validated in Flow Cytometry, IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
![]() Anti- Beta-tubulin Monoclonal Antibody |
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M05613-3 | BosterBio | 100ul | EUR 397 |
Description: Mouse Monoclonal Beta-tubulin Antibody. Validated in IHC, WB and tested in Human, Monkey, Mouse, Rat. |
![]() Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
![]() Anti-Mutant p53 Rabbit Monoclonal Antibody |
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M00001-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal Mutant p53 Antibody. Validated in IP, IF, WB and tested in Human. |
![]() Anti-Caspase-8 Monoclonal Antibody (5F7) |
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M00042-3 | BosterBio | 100ug | EUR 420 |
Description: Mouse Monoclonal Caspase-8 Antibody (5F7). Validated in IP, IHC, WB and tested in Human. |
![]() Anti-Caspase-9 Rabbit Monoclonal Antibody |
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M00080-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal Caspase-9 Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
![]() Anti-CDK1/Cdc2 Rabbit Monoclonal Antibody |
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M00209-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal CDK1/Cdc2 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
![]() Anti-Cyclin B1 Rabbit Monoclonal Antibody |
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M00745-3 | BosterBio | 100ug/vial | EUR 397 |
Description: Rabbit Monoclonal Cyclin B1 Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
Molecular Mechanism of HER2 Fast Internalization and Redirected Trafficking Induced by Anti-HER2 BiparatopicAntibody
- Amplification and overexpression of HER2 (human epidermal development issue receptor 2), an ErbB2 receptor tyrosine kinase, have been implicated in human most cancers and metastasis. A bispecific tetravalent anti-HER2 antibody (anti-HER2-Bs), focusing on two non-overlapping epitopes on HER2 in area IV (trastuzumab) and area II (39S), has been reported to induce speedy internalization and environment friendly degradation of HER2 receptors.
- On this research, we investigated the molecular mechanism of this antibody-induced speedy HER2 internalization and intracellular trafficking. Utilizing quantitative fluorescent imaging, we in contrast the internalization kinetics of anti-HER2-Bs and its parental arm antibodies, alone or in mixtures and beneath numerous internalization-promoting circumstances. The outcomes demonstrated that concurrent engagement of each epitopes was crucial for speedy anti-HER2-Bs internalization.
- Mobile uptake of anti-HER2-Bs and parental arm antibodies occurred by way of clathrin-dependent endocytosis; nonetheless, contained in the cells antibodies directed totally different trafficking pathways. Trastuzumab dissociated from HER2 in 2 h, enabling the receptor to recycle, whereas anti-HER2-Bs stayed related to the receptor all through the whole endocytic pathway, selling receptor ubiquitination, trafficking to the lysosomes, and environment friendly degradation.
- In keeping with routing HER2 to degradation, anti-HER2-Bs considerably decreased HER2 shedding and altered its exosomal export. Collectively, these outcomes allow a greater understanding of the mechanism of motion of anti-Her2-Bs and may information the rational design of anti-HER2 therapeutics in addition to different bispecific molecules.
Receptor-binding domain-specific human neutralizing monoclonal antibodies in opposition to SARS-CoV and SARS-CoV-2
The outbreaks of extreme acute respiratory syndrome (SARS) and Coronavirus Illness 2019 (COVID-19) brought on by SARS-CoV and SARS-CoV-2, respectively, have posed extreme threats to world public well being and the economic system. Therapy and prevention of those viral illnesses name for the analysis and growth of human neutralizing monoclonal antibodies (NMAbs).
Scientists have screened neutralizing antibodies utilizing the virus receptor-binding area (RBD) as an antigen, indicating that RBD incorporates a number of conformational neutralizing epitopes, that are the principle structural domains for inducing neutralizing antibodies and T-cell immune responses. This assessment summarizes the construction and performance of RBD and RBD-specific NMAbs in opposition to SARS-CoV and SARS-CoV-2 at the moment beneath growth.
![]() Mouse Ferroportin (FPN) ELISA Kit |
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RD-FPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 740 |
![]() Human Ferroportin (FPN) ELISA Kit |
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DLR-FPN-Hu-48T | DL Develop | 48T | EUR 517 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Ferroportin (FPN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Ferroportin (FPN) ELISA Kit |
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DLR-FPN-Hu-96T | DL Develop | 96T | EUR 673 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Ferroportin (FPN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Rat Ferroportin (FPN) ELISA Kit |
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DLR-FPN-Ra-48T | DL Develop | 48T | EUR 549 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Ferroportin (FPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Rat Ferroportin (FPN) ELISA Kit |
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DLR-FPN-Ra-96T | DL Develop | 96T | EUR 718 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Ferroportin (FPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Human Ferroportin (FPN) ELISA Kit |
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RDR-FPN-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 544 |
![]() Human Ferroportin (FPN) ELISA Kit |
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RDR-FPN-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 756 |
![]() Rat Ferroportin (FPN) ELISA Kit |
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RDR-FPN-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 583 |
![]() Rat Ferroportin (FPN) ELISA Kit |
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RDR-FPN-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 811 |
![]() Human Ferroportin (FPN) ELISA Kit |
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RD-FPN-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 521 |
![]() Human Ferroportin (FPN) ELISA Kit |
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RD-FPN-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 723 |
![]() Rat Ferroportin (FPN) ELISA Kit |
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RD-FPN-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
![]() Rat Ferroportin (FPN) ELISA Kit |
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RD-FPN-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 775 |
![]() Ferroportin (FPN) Monoclonal Antibody (Human) |
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4-MAC489Hu24 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN) |
![]() Ferroportin (FPN) Antibody |
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20-abx176382 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx176383 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx176384 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx100509 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx132071 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx132072 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx132073 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx172368 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx172369 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx270157 | Abbexa |
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![]() Ferroportin (FPN) Antibody |
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20-abx270158 | Abbexa |
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![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig) |
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4-MAC489Hu21 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN) |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), APC |
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4-MAC489Hu24-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with APC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), Biotinylated |
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4-MAC489Hu24-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with Biotin. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), Cy3 |
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4-MAC489Hu24-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with Cy3. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), FITC |
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4-MAC489Hu24-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with FITC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), HRP |
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4-MAC489Hu24-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with HRP. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), PE |
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4-MAC489Hu24-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with PE. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat) |
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4-MAC489Hu26 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN) |
![]() Mouse Ferroportin (FPN) Protein |
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20-abx653356 | Abbexa |
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![]() Mouse Ferroportin (FPN) Protein |
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20-abx653357 | Abbexa |
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![]() Recombinant Ferroportin (FPN) |
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4-RPC489Hu01 | Cloud-Clone |
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Description: Recombinant Human Ferroportin expressed in: E.coli |
![]() Ferroportin (FPN) Antibody (FITC) |
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20-abx270455 | Abbexa |
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![]() Ferroportin (FPN) Antibody (FITC) |
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20-abx270456 | Abbexa |
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![]() Ferroportin (FPN) Antibody (APC) |
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20-abx270687 | Abbexa |
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![]() Ferroportin (FPN) Antibody (APC) |
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20-abx270688 | Abbexa |
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![]() Ferroportin (FPN) Antibody (PE) |
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20-abx270919 | Abbexa |
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![]() Ferroportin (FPN) Antibody (PE) |
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20-abx270920 | Abbexa |
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![]() Ferroportin (FPN) Antibody (Biotin) |
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20-abx272276 | Abbexa |
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![]() Ferroportin (FPN) Antibody Pair |
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20-abx370570 | Abbexa |
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![]() Ferroportin (FPN) Antibody (Biotin) |
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20-abx274456 | Abbexa |
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![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), APC |
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4-MAC489Hu21-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with APC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), Biotinylated |
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4-MAC489Hu21-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with Biotin. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), Cy3 |
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4-MAC489Hu21-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with Cy3. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), FITC |
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4-MAC489Hu21-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with FITC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), HRP |
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4-MAC489Hu21-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with HRP. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), PE |
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4-MAC489Hu21-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with PE. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human), APC-Cy7 |
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4-MAC489Hu24-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Ferroportin (FPN). This antibody is labeled with APC-Cy7. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), APC |
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4-MAC489Hu26-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with APC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), Biotinylated |
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4-MAC489Hu26-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with Biotin. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), Cy3 |
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4-MAC489Hu26-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with Cy3. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), FITC |
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4-MAC489Hu26-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with FITC. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), HRP |
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4-MAC489Hu26-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with HRP. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), PE |
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4-MAC489Hu26-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with PE. |
![]() Mouse Ferroportin (FPN) ELISA Kit |
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20-abx153994 | Abbexa |
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![]() Mouse Ferroportin (FPN) ELISA Kit |
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abx570953-96tests | Abbexa | 96 tests | EUR 786 |
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![]() Mouse Ferroportin (FPN) CLIA Kit |
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20-abx493728 | Abbexa |
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![]() Mouse Ferroportin (FPN) ELISA Kit |
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SEC489Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4862.4 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ferroportin (FPN) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Mouse Ferroportin (FPN) ELISA Kit |
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SEC489Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 488.08 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ferroportin (FPN) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Mouse Ferroportin (FPN) ELISA Kit |
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SEC489Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 654.4 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ferroportin (FPN) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Mouse Ferroportin (FPN) ELISA Kit |
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SEC489Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2644.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Ferroportin (FPN) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Mouse Ferroportin (FPN) ELISA Kit |
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4-SEC489Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Ferroportin (FPN) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() Mouse Ferroportin ELISA Kit (FPN) |
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RK02817 | Abclonal | 96 Tests | EUR 521 |
![]() Mouse Ferroportin(FPN)ELISA kit |
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QY-E20566 | Qayee Biotechnology | 96T | EUR 361 |
![]() Human Ferroportin (FPN) Protein |
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20-abx066553 | Abbexa |
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![]() Rat Ferroportin (FPN) Protein |
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20-abx653358 | Abbexa |
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![]() Ferroportin (FPN) Polyclonal Antibody (Human) |
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4-PAC489Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Ferroportin (FPN) |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Pig), APC-Cy7 |
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4-MAC489Hu21-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Pig Ferroportin (FPN). This antibody is labeled with APC-Cy7. |
![]() Ferroportin (FPN) Monoclonal Antibody (Human, Rat), APC-Cy7 |
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4-MAC489Hu26-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human, Rat Ferroportin (FPN). This antibody is labeled with APC-Cy7. |
![]() ELISA kit for Mouse FPN (Ferroportin) |
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E-EL-M0767 | Elabscience Biotech | 1 plate of 96 wells | EUR 534 |
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Description: A sandwich ELISA kit for quantitative measurement of Mouse FPN (Ferroportin) in samples from Serum, Plasma, Cell supernatant |
![]() ELISA kit for Mouse FPN (Ferroportin) |
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ELK6283 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Ferroportin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Ferroportin (FPN) Polyclonal Antibody (Human), APC |
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4-PAC489Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Ferroportin (FPN). This antibody is labeled with APC. |
![]() Ferroportin (FPN) Polyclonal Antibody (Human), Biotinylated |
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4-PAC489Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Ferroportin (FPN). This antibody is labeled with Biotin. |
![]() Ferroportin (FPN) Polyclonal Antibody (Human), Cy3 |
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4-PAC489Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Ferroportin (FPN). This antibody is labeled with Cy3. |
![]() |